Anti-SLC22A12 Antibody

Raised in Rabbit and affinity purified against a human SLC22A12-derived immunogen, this unconjugated polyclonal IgG reagent from Antibodies.com recognizes URAT1, the apical renal urate-anion transporter that mediates reabsorption of uric acid across the proximal tubule epithelium and regulates serum urate levels. The antibody is validated for Western blot analysis of lysates from Human, Mouse, and Rat samples, where it detects the native, glycosylated transporter near 60-70 kDa. Each lot is verified by immunoblotting before release and is supplied as 100 µl of liquid in a single vial. The reagent supports research into renal tubular urate transport, hyperuricemia, renal hypouricemia type 1 caused by SLC22A12 mutations, gout pathophysiology, and the mechanism of uricosuric agents that act on URAT1, including probenecid, lesinurad, and benzbromarone. For research use only. Store at 4 °C for short-term use; aliquot and freeze at -20 °C for longer-term storage and avoid repeated freeze-thaw cycles.