Anti-SLC1A4 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets SLC1A4, a sodium-dependent neutral amino acid transporter also known as ASCT1 (Alanine-Serine-Cysteine Transporter 1). The reagent is supplied as 100 µl of polyclonal antiserum validated for western blot (WB) and immunohistochemistry (IHC) on human samples, with confirmed reactivity against human SLC1A4.

SLC1A4 belongs to the SLC solute carrier family and mediates sodium-coupled uptake of small neutral amino acids across the plasma membrane. The transporter is broadly expressed across tissues such as brain, lung, kidney, and placenta, and has been linked to neural development and amino acid metabolism in the central nervous system. Recessive loss-of-function variants in SLC1A4 cause spastic tetraplegia, thin corpus callosum, and progressive microcephaly syndrome (SPATCCM), making the protein a target of interest in neurological and developmental disease research.

For best stability, aliquot the antibody upon receipt and store at -20°C, avoiding repeated freeze-thaw cycles. The unconjugated format allows flexible pairing with secondary reagents for western blot or IHC workflows.