Anti-SLC18A2 Antibody

Raised in rabbits and affinity-purified against recombinant full-length human SLC18A2, this unconjugated polyclonal IgG reagent recognizes endogenous VMAT2 (vesicular monoamine transporter 2), a ~55 kDa synaptic vesicle protein that loads dopamine, serotonin, norepinephrine, epinephrine, and histamine into monoaminergic nerve terminals. Researchers studying Parkinson's disease, schizophrenia, mood disorders, tardive dyskinesia, and Huntington's disease use VMAT2 detection to map dopaminergic circuits and assess monoaminergic signaling integrity.

Validated for western blot and immunohistochemistry, the antibody detects endogenous SLC18A2 in lysates and tissue sections from human, mouse, and rat samples, supporting comparative neurobiology studies across species. The unconjugated format lets laboratories pair the reagent with HRP, biotin, Alexa Fluor, or alkaline phosphatase reporters matched to their workflow, and the polyclonal IgG pool broadens epitope coverage for immunoblotting and tissue-staining protocols.

Supplied at 1 mg/ml in phosphate-buffered saline containing 0.1% sodium azide and 50% glycerol, the 50 µl vial ships on cold gel packs and should be stored at -20 °C after arrival. Antibodies.com aliquots each lot for research use only, and customers should avoid repeated freeze-thaw cycles to preserve binding activity.