Anti-SLC18A2 Antibody

VMAT2, the vesicular monoamine transporter encoded by SLC18A2, packages dopamine, serotonin, norepinephrine, and histamine into synaptic vesicles and is widely studied in neuroscience research. This Antibodies.com polyclonal reagent binds the human, mouse, and rat SLC18A2 protein for detection by Western blot (WB) and immunohistochemistry (IHC).

Supplied as 200 µl of unconjugated rabbit IgG, the antibody gives researchers flexibility to conjugate HRP, biotin, or a fluorophore of their choice. Polyclonal coverage is well suited to mapping native transporter distribution in dopaminergic midbrain neurons, striatal terminals, and pancreatic beta cells, where SLC18A2 is also expressed.

Typical applications include characterization of Parkinson's disease models, monoamine signaling in addiction circuits, and pharmacological profiling of VMAT2 inhibitors such as reserpine and tetrabenazine.