Anti-SLC16A3 Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody from Antibodies.com targets the monocarboxylate transporter SLC16A3, also known as MCT4, a proton-linked plasma membrane carrier responsible for exporting lactate and pyruvate from highly glycolytic cells.

The antibody is validated for Western blot and immunohistochemistry applications and shows reactivity against human, mouse, and rat samples, supporting comparative studies across species and tissue types. Supplied in a 100 µl vial of ready-to-use reagent, it fits standard immunoblotting and chromogenic detection workflows in research laboratories.

SLC16A3/MCT4 is widely used as a marker of glycolytic flux and is upregulated under hypoxic conditions through HIF-1α signaling. The reagent supports investigations into tumor metabolism, the Warburg effect, hypoxia signaling, and the astrocyte-neuron lactate shuttle, where transporter expression is a key readout of metabolic state. Researchers studying exercise physiology, cancer cell bioenergetics, or immunometabolism can use it to map MCT4 localization in skeletal muscle fibers, hypoxic tumor regions, or activated immune cells.

Unconjugated format allows flexible choice of secondary detection reagents and supports both fluorescent and chromogenic readouts depending on experimental design.