Anti-SLC16A2 Antibody

The SLC16A2 gene encodes Monocarboxylate Transporter 8 (MCT8), a transmembrane thyroid hormone transporter critical for T3 uptake across the blood-brain barrier and into neural tissue. Loss-of-function variants in this X-linked gene cause Allan-Herndon-Dudley syndrome, a severe neurodevelopmental disorder characterized by profound intellectual disability and abnormal circulating thyroid hormone profiles.

This rabbit polyclonal antibody from Antibodies.com is raised against SLC16A2 and validated for Western blot detection in human, mouse, and rat samples. The reagent is supplied as 100 µl of unconjugated antibody at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide, at approximately pH 7.2. Researchers investigating MCT8 trafficking, neuronal thyroid hormone signaling, or X-linked intellectual disability can use this polyclonal reagent to probe endogenous protein levels across rodent and human model systems. The vial should be stored refrigerated at 4 °C in the original buffer to preserve activity across repeated freeze-thaw cycles, and aliquoting upon first use is recommended to limit handling of the stock.