Anti-SLC15A1 Antibody

Offered by Antibodies.com, this rabbit polyclonal antibody is raised against SLC15A1 and is unconjugated. It is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2. The antibody is validated for Western blot (WB) applications and shows reactivity with human, mouse, and rat samples.

In mammalian small intestine, the proton-coupled peptide transporter (PEPT) is responsible for the absorption of small peptides arising from digestion of dietary proteins. PEPT1, a hydrogen ion/peptide cotransporter, transports dipeptides and tripeptides, but not free amino acids or peptides with more than three amino acid residues. Its driving force for uphill transport requires proton binding and the presence of an inside-negative membrane potential. PEPT1 is a 708 amino acid protein that contains 12 putative membrane-spanning domains. PEPT1 is expressed in Caco-2 cells and seems to play important roles in nutritional and pharmacological therapies. The mammalian kidney expresses a proton-coupled peptide transporter, PEPT2, that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate.