Anti-SLC12A6 Antibody

Raised in rabbit against the K-Cl cotransporter 3 (KCC3) encoded by SLC12A6, this polyclonal IgG reagent from Antibodies.com enables immunofluorescence detection of the membrane transporter on human cells and tissue sections. The unconjugated antiserum is supplied as a 50 µl liquid aliquot, allowing direct conjugation with user-preferred fluorochromes for cell and tissue imaging workflows. SLC12A6 is a 12-transmembrane-domain protein that lowers intracellular chloride below electrochemical equilibrium and is activated by cell swelling under hypotonic conditions, with loss-of-function mutations linked to hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC, Andermann syndrome). Recommended handling: aliquot upon arrival, store at -20 °C, avoid repeated freeze-thaw cycles, and centrifuge briefly before opening to recover full volume. The polyclonal format recognizes multiple epitopes across the KCC3 polypeptide, providing consistent signal on fixed specimens in immunofluorescence assays. For research use only.