Anti-SLC12A1 Antibody

The SLC12A1 gene encodes the renal sodium-potassium-chloride cotransporter NKCC2, a key transporter localized to the apical membrane of thick ascending limb cells in the kidney. This rabbit polyclonal antibody from Antibodies.com is raised against SLC12A1 and validated for Western blot and immunohistochemistry workflows on human samples.

The unconjugated format supports flexible assay design, allowing researchers to pair it with their own secondary detection reagents for immunofluorescence, chromogenic, or chemiluminescent readouts. Each vial contains 100 µl of antiserum for probing NKCC2 expression patterns in renal tissue sections and cell lysates.

Polyclonal reactivity offers broader epitope coverage than monoclonal alternatives, an advantage when probing conservation across SLC12A1 isoforms or detecting low-abundance targets. The reagent is intended for research use only and supports studies of renal physiology, salt handling, hypertension mechanisms, and inherited tubulopathies such as Bartter syndrome type I, where SLC12A1 loss-of-function mutations disrupt loop of Henle sodium reabsorption.