Anti-SLC10A1 Antibody

This rabbit polyclonal IgG antibody recognizes SLC10A1 (also known as NTCP, the Na⁺/taurocholate co-transporting polypeptide), a multi-pass transmembrane transporter anchored on the basolateral membrane of hepatocytes. From Antibodies.com, the unconjugated reagent is supplied as a 200 µl vial of polyclonal antiserum validated for Western blot detection across human, mouse, and rat samples.

NTCP drives the sodium-dependent uptake of conjugated bile acids from portal blood into hepatocytes, placing it at the center of research on bile acid homeostasis, cholestatic liver disease, and enterohepatic circulation. The protein is equally well known as the surface receptor that mediates Hepatitis B and Hepatitis D virus entry into hepatocytes, so this reagent is widely used in hepatology and virology laboratories studying viral entry mechanisms, hepatocyte polarization, and drug-transporter interactions.

For handling, aliquot the antibody and store at -20°C in single-use portions to limit freeze-thaw cycles and protect from light; working dilutions can be kept refrigerated for short-term use. On Western blots, the signal typically resolves near the predicted ~38 kDa band, with shifts possible due to glycosylation and other post-translational modifications.