Anti-Slap Antibody

SLAP (Src-like adaptor protein) functions as a negative regulator of receptor tyrosine kinase signaling in lymphocytes, recruiting the Cbl family of E3 ubiquitin ligases to downregulate activated receptors at the cell surface. This rabbit polyclonal reagent from Antibodies.com is raised against human Slap and validated for western blot and immunofluorescence detection in standard laboratory workflows.

The unconjugated format is supplied as 100 µl of polyclonal antiserum, giving researchers flexibility to optimize working dilution across PVDF or nitrocellulose membranes as well as fixed-cell imaging preparations. Applications include studies of T-cell receptor signaling, B-cell receptor downregulation, clathrin-mediated endocytosis, and receptor ubiquitination pathways in immune cell lines and primary human tissue samples.

Because the antibody is unconjugated, it pairs cleanly with HRP-, biotin-, or fluorophore-conjugated secondary reagents and is compatible with standard indirect immunolabeling, chemiluminescence, and confocal imaging workflows. For best results, aliquot on receipt and store refrigerated between uses; protect from light and avoid repeated freeze-thaw cycles to preserve antigen-binding activity.