Anti-SLAMF7 Antibody

This unconjugated rabbit polyclonal primary antibody recognizes SLAMF7, a glycosylated type I transmembrane receptor of the SLAM family that modulates activating and inhibitory signaling in innate immune cells. SLAMF7 is heavily studied in multiple myeloma research, where it is overexpressed on malignant plasma cells and serves as the molecular target of the therapeutic antibody elotuzumab. Supplied as a 100 µl aliquot and validated for western blot (WB) and immunohistochemistry (IHC) workflows on human specimens, the antibody supports studies of receptor expression in lymphoid tissue, NK cell biology, and myeloma cell line models.

Raised in rabbit, this polyclonal reagent binds multiple epitopes across the SLAMF7 extracellular and intracellular domains, providing consistent detection in both denatured western blot lysates and formalin-fixed, paraffin-embedded tissue sections. Because the antibody is delivered unconjugated, researchers can couple it to HRP, biotin, fluorophores, or colloidal gold to match their preferred detection chemistry. Investigators at Antibodies.com apply this reagent to characterize immune synapse formation, NK cell-mediated cytotoxicity, and CD138+ plasma cell populations in bone marrow biopsies.

Each vial should be briefly centrifuged before opening to recover the full liquid volume. For routine use, keep the working stock refrigerated and protected from light; for extended storage, freeze in single-use aliquots to minimize repeated freeze-thaw cycles and preserve antigen-binding activity over time.