Anti-Skp2 p45 Antibody

This polyclonal reagent from Antibodies.com targets Skp2 p45, the 45 kDa isoform of the F-box protein Skp2 (also known as FBXL1) that forms part of the SCF E3 ubiquitin ligase complex responsible for ubiquitinating cell cycle regulators such as p27/Kip1. Raised in rabbit and supplied unconjugated in a 100 µl vial, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows against human samples. Researchers studying G1/S transition, cyclin-dependent kinase regulation, and oncogenic signalling pathways apply it to probe Skp2 overexpression in tumor tissue and to investigate proteasome-dependent turnover of its substrates. The polyclonal format provides recognition of multiple epitopes, supporting consistent signal in IHC of formalin-fixed sections and in WB of whole-cell lysates. Store refrigerated in single-use aliquots and limit freeze-thaw cycles to preserve antibody activity over time.