Anti-SKIV2L2 Antibody

This polyclonal reagent from Antibodies.com is raised in rabbit against SKIV2L2 (Ski2 Like RNA Helicase 2), a putative ATP-dependent RNA helicase that contributes to nuclear RNA surveillance and exosome-mediated turnover of aberrant transcripts, including improperly processed snRNAs, snoRNAs, and untranslated decay intermediates. The antibody is supplied unconjugated at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, and is validated for Western blot and immunohistochemistry on human, mouse, and rat tissue sections and lysates, making it suitable for studying transcription termination, ribosome biogenesis quality control, and the cellular response to defective RNA processing. Each 100 µL vial is provided ready to dilute and titrate for immunostaining; researchers commonly employ concentrations in the 1-5 µg/ml range for blotting and 1-10 µg/ml for tissue staining, with overnight primary incubation at 2-8 °C. For long-term stability, store the antibody at -20 °C in working aliquots, avoid repeated freeze-thaw cycles, and protect from light to preserve antigen-binding activity. Intended for research use only, this primary antibody supports workflows in RNA biology, helicase mechanism studies, and investigations of the SKIV2L2/MTR4-containing RNA decay pathways.