Anti-SKIV2L2 Antibody

SKIV2L2, also known as MTR4, is a nuclear RNA helicase that functions as an essential cofactor of the RNA exosome complex, where it participates in the surveillance and turnover of aberrant ribosomal RNA transcripts and other non-coding RNAs. This unconjugated rabbit polyclonal IgG antibody from Antibodies.com was raised against SKIV2L2 and is validated for western blot, immunohistochemistry, and flow cytometry applications. The reagent cross-reacts with both human and mouse orthologs, supporting comparative work across standard mammalian model systems. Supplied at 100 µl per vial, the polyclonal composition recognizes multiple epitopes on the target helicase, helping to reveal endogenous SKIV2L2 across varying expression levels in cell lysates, fixed tissue sections, and suspended cell populations. Investigators studying ribosome assembly quality control, RNA processing, and the interface between transcription and RNA decay use anti-SKIV2L2 reagents to localize the helicase within the nucleolus and to follow exosome-dependent RNA turnover under different cellular conditions. Each vial is intended for research use only.