Anti-SIRT4 Antibody

Raised in rabbit hosts, this polyclonal reagent from Antibodies.com binds human SIRT4, a mitochondrial matrix-localized sirtuin family member characterized by NAD+-dependent ADP-ribosyltransferase activity. The unconjugated antibody is supplied as 100 µl per vial and is validated for Western blot and immunohistochemistry workflows, supporting studies of metabolic regulation, glutamine catabolism, and DNA damage response pathways in human samples.

SIRT4 contributes to mitochondrial function through modification of enzymes such as glutamate dehydrogenase, linking nutrient sensing to insulin secretion and cellular energy balance. Investigators studying type 2 diabetes, cancer metabolism, and mitochondrial biology use this reagent to probe SIRT4 expression in cultured cell lines and fixed tissue sections.

Storage should follow standard antibody handling practice: refrigerate the vial, protect from light, and prepare working aliquots to limit repeated freeze-thaw cycles that can degrade polyclonal activity. The buffer formulation is compatible with common chromogenic and chemiluminescent detection chemistries, allowing direct dilution into established protocols without further purification.