Anti-SIRT2 Antibody

Raised in rabbit hosts against the NAD+-dependent deacetylase SIRT2, this unconjugated polyclonal antibody from Antibodies.com detects an endogenous target conserved across human, mouse, and rat samples. The reagent is supplied as a 100 µL vial and is validated for Western blot and immunohistochemistry, giving labs a single primary reagent for both protein-level detection in lysates and localization work in fixed tissue sections.

SIRT2 is best characterized as a cytoplasmic class III deacetylase that modifies histone H4 lysine 16 and histone H3 lysine 56, as well as non-histone substrates including α-tubulin. Researchers therefore use the antibody to study G2/M cell cycle checkpoint control, mitotic exit, chromatin remodeling, and chromatin immunoprecipitation follow-up. The reagent pairs cleanly with custom HRP, fluorophore, or biotin labeling chemistries for immunofluorescence and immunoprecipitation experiments. Common application areas include metabolic regulation, neurodegeneration, and tumor biology, where the unconjugated format supports flexible detection on different imaging and blotting platforms.