Anti-SIRT1 Antibody

This polyclonal antibody from Antibodies.com targets SIRT1 (Sirtuin 1), a NAD+-dependent class III histone deacetylase that regulates chromatin structure, gene transcription, and protein stability through deacetylation of histone and non-histone substrates including p53, FOXO transcription factors, and NF-κB.

Validated for western blot, immunohistochemistry, and ELISA applications, the reagent is raised in rabbit and supplied as an unconjugated antiserum at 100 µl volume per vial. The antibody has been confirmed to react with both human and mouse SIRT1, supporting cross-species studies in cell biology, aging research, metabolic disease models, and oncology workflows where sirtuin-mediated deacetylation pathways are investigated.

As a research use only reagent, this SIRT1 antibody enables studies of longevity signaling, DNA damage response, mitochondrial biogenesis, and epigenetic regulation. The polyclonal format provides broader epitope recognition compared to monoclonal alternatives, which is advantageous when examining post-translational modifications, mapping expression across different tissue contexts, or working with samples where epitope accessibility may vary.