Anti-SIRT1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets human SIRT1 (Sirtuin 1), an NAD+-dependent class III histone deacetylase implicated in chromatin remodeling, DNA damage response, metabolic homeostasis, and cellular senescence. Raised in rabbit and supplied as 100 µl of unconjugated whole antiserum, the reagent is validated for western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation workflows, supporting studies of acetylated histone marks, transcription factor regulation, and stress-response signaling in human cell and tissue samples.

SIRT1 deacetylates substrates such as p53, FOXO transcription factors, NF-κB, and histones H3 and H4, making this antibody useful for research into aging pathways, calorie-restriction biology, and oncogenic signaling networks. Researchers probing mitochondrial biogenesis, circadian gene regulation, or glucocorticoid receptor activity will find the polyclonal format advantageous when epitope diversity is required across SIRT1 isoforms or post-translational modification states. Reactivity is confirmed for human SIRT1 across the listed assay applications. Aliquot upon arrival, refrigerate, and protect from light to preserve activity for repeated chromatin immunoprecipitation and immunoprecipitation experiments; avoid repeated freeze-thaw cycles to maintain target affinity.