Anti-Sirp α1 Antibody

This unconjugated polyclonal antibody from Antibodies.com targets Signal Regulatory Protein Alpha 1 (Sirpα1), a transmembrane immunoglobulin superfamily receptor best known for engaging CD47 on neighbouring cells and delivering inhibitory signals through cytoplasmic ITIM motifs. Raised in rabbit, the reagent is supplied as 100 µl of stock in a vial, with no fluorophore or enzyme attached, so it slots directly into chromogenic and chemiluminescent workflows.

Validated for Western Blot and Immunohistochemistry, the antibody recognises conserved epitopes present in human, mouse and rat Sirpα1, making it useful across rodent disease models and human tissue cohorts. Researchers studying the CD47–SIRPα checkpoint, macrophage biology, tumour immune evasion, dendritic-cell maturation, or neutrophil migration rely on this reagent to map receptor expression in tissue sections and on immunoblots.

Because the product is unconjugated and polyclonal, it can be paired with secondary reagents such as anti-rabbit HRP, biotin, or fluorophore conjugates and adapted to multiplex staining panels. Aliquoting on first use is recommended to limit freeze-thaw cycles and preserve lot-to-lot consistency for longitudinal studies.