Anti-SIP1 Antibody

This polyclonal antibody recognizes SIP1, also referred to as GEMIN2, a core component of the SMN complex that drives small nuclear ribonucleoprotein (snRNP) assembly in eukaryotic cells. SIP1 directly binds SMN and is essential for the regeneration of U snRNPs required during pre-mRNA splicing. Loss-of-function mutations affecting SIP1 are tied to spinal muscular atrophy pathophysiology, which keeps the protein a recurring target in motor neuron disease research.

Raised in rabbit and supplied unconjugated, the reagent is validated for Western blot, immunohistochemistry, and ELISA workflows. Reported cross-reactivity covers human, mouse, and rat samples, supporting translational work that ranges from rodent disease models to patient-derived tissue. The product is provided as a 100 µl liquid aliquot in a single vial. Refrigerate on arrival and limit freeze-thaw cycles to preserve binding activity.

Researchers studying spliceosomal biogenesis, motor neuron degeneration, or SMN complex composition routinely use this reagent to detect SIP1 bands at the expected molecular weight on immunoblots and to localize the protein in neural and non-neural tissue sections. Each lot from Antibodies.com ships with validation data so users can confirm specificity in their particular assay setup before scaling up experiments.