Anti-SIGMAR1 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets SIGMAR1 (sigma-1 receptor), an endoplasmic reticulum chaperone protein implicated in ion channel modulation, intracellular calcium signaling, and cellular survival pathways. Raised in rabbit and supplied as 100 µL of liquid antiserum, the reagent is validated for western blot and immunohistochemistry workflows across human, mouse, and rat sample types, supporting neuroscience, neuropharmacology, and neurodegeneration research programs.

The sigma-1 receptor, additionally referenced as OPRS1 and SR-BP, has emerged as a focal point in studies of neuroplasticity, neuropathic pain, and disorders including amyotrophic lateral sclerosis, Alzheimer's disease, and substance use disorders, making reliable detection antibodies valuable for mapping receptor distribution and expression dynamics. Store the vial at -20 °C in working aliquots to minimize freeze-thaw cycles, and refer to the enclosed datasheet for recommended dilutions, antigen retrieval conditions for IHC, and blocking strategies for immunoblotting.