Anti-SIGMAR1 Antibody

This polyclonal antibody from Antibodies.com targets SIGMAR1, the sigma-1 receptor chaperone protein that resides at the endoplasmic reticulum-mitochondria interface. Raised in rabbit, the reagent is supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, compatible with Western blot and immunohistochemistry workflows on human, mouse, and rat samples.

SIGMAR1 operates as a ligand-operated chaperone that modulates inositol triphosphate receptor calcium signaling, voltage-gated ion channels, and ER stress responses, and it has been studied in models of neurodegeneration, neuropathic pain, and retinal ganglion cell survival. The unconjugated format leaves detection chemistry open, letting users pair the reagent with HRP, fluorophore, or biotin reporters selected for their own assay pipeline.

Aliquot upon first use to limit freeze-thaw cycles, store refrigerated, and protect from light. For research use only; not validated for diagnostic or therapeutic applications. The polyclonal composition provides multi-epitope coverage of the approximately 25 kDa SIGMAR1 target, which can be useful when probing post-translational modifications or splice variants of this receptor.