Anti-SIGLEC7 Antibody

Raised in rabbits against human sialic acid-binding immunoglobulin-like lectin 7 (SIGLEC7), this unconjugated polyclonal IgG reagent from Antibodies.com detects an inhibitory receptor classically associated with natural killer (NK) cell biology, where SIGLEC7 modulates cytotoxic responses through engagement of sialylated glycan ligands. Supplied as a 100 µl aliquot, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples. Investigators profiling NK receptor repertoires, dissecting innate immune checkpoint signaling, characterizing tumor immune microenvironments, and exploring sialic-acid-mediated cell–cell communication rely on this reagent for endogenous SIGLEC7 detection across denaturing and fixed-tissue conditions. The polyclonal format offers multi-epitope coverage, supporting robust signal-to-noise in heterogeneous tissue preparations where epitope masking is a concern. Optimization of antigen retrieval and serum blocking is recommended for IHC, particularly when working with heavily cross-linked fixatives. Intended for research use only and not validated for diagnostic applications.