Anti-SIGLEC6 Antibody

SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6) is a cell-surface glycoprotein best known for its expression on placental trophoblasts and on a subset of mast cells and B lymphocytes, where it modulates sialylated glycan recognition and innate immune signaling. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the human target and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, making it a practical tool for investigators studying trophoblast biology, pregnancy-related immunology, or the growing interest in SIGLEC6 as a surface marker on certain solid tumours and leukaemic blasts.

Because SIGLEC6 also functions as an alternative receptor for leptin, the antibody is useful in studies probing the cross-talk between metabolic hormones and the placenta, as well as in cancer research where SIGLEC6-positive trophoblastic tumours and choriocarcinomas are routinely characterised. The polyclonal format provides recognition of multiple epitopes across the protein, which can be advantageous when working with partially denatured samples for Western blot or with formalin-fixed paraffin-embedded tissue for IHC. The reagent is supplied as a 100 µl liquid aliquot, reacts specifically with human SIGLEC6, and supports reliable detection in cell lysates and tissue sections under standard laboratory protocols.