Anti-Siah-1 / 2 Antibody

The Siah family of RING finger E3 ubiquitin ligases (Seven in Absentia Homologs) drives ubiquitin-mediated degradation of substrates tied to apoptosis, hypoxia response, and neuronal stress signaling, making them widely studied targets in neurodegeneration and cancer biology. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against Siah-1 and also recognizes the closely related Siah-2 paralog, supporting western blot, immunohistochemistry, immunofluorescence, and ELISA workflows across human, mouse, and rat samples. Supplied as 100 µl of polyclonal antibody, the reagent enables qualitative detection of endogenous Siah proteins in cell lysates and tissue sections, and can be paired with HRP- or fluorophore-conjugated secondary antibodies for chromogenic or fluorescent readout in cell-based assays probing proteasome-dependent turnover pathways.