Anti-SHP-2 Antibody

Affinity-purified polyclonal reagent from Antibodies.com, raised in rabbit against the protein-tyrosine phosphatase SHP-2 (PTPN11). This unconjugated primary antibody is supplied as a 50 µl liquid formulation at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, providing a concentrated working stock that can be diluted directly into assay buffers. Validated applications include Western blot (WB) and immunohistochemistry (IHC), making it a practical choice for studies of SHP-2 expression and signaling in human, mouse, and rat samples. The host species is rabbit and the clonality is polyclonal, with reactivity confirmed across human, mouse, and rat tissues, so the same lot can be used across multiple model systems. Each batch is affinity-purified by antigen-affinity chromatography to reduce non-specific binding and is intended for research use only. For best results, store the antibody at -20 °C in working aliquots to preserve activity and avoid repeated freeze-thaw cycles. The reagent is well suited for laboratories investigating the role of SHP-2 in receptor tyrosine kinase, cytokine, and integrin signaling pathways, including downstream RAS/MAPK cascade research and phospho-tyrosine studies. SHP-2 is a cytoplasmic tyrosine phosphatase that acts downstream of many receptors and is widely implicated in development, immune cell function, and cancer biology, and a robust polyclonal reagent such as this provides a flexible tool for both total-protein detection and validation of knockdown or knockout phenotypes.