Anti-SHP-2 Antibody

SHP-2 (Src homology 2 domain-containing protein tyrosine phosphatase-2) is a cytoplasmic tyrosine phosphatase encoded by the PTPN11 gene that regulates RAS/MAPK and PI3K/AKT signaling downstream of receptor tyrosine kinases and is implicated in Noonan syndrome, LEOPARD syndrome, and certain leukemias. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against SHP-2 and validated for Western blot and immunohistochemistry on human, mouse, and rat samples. The reagent is supplied as 100 µl of a 1 mg/ml stock in PBS containing 0.1% sodium azide and 50% glycerol, which stabilises the antibody for long-term storage at -20 °C with minimal freeze-thaw loss. The polyclonal format provides recognition of several epitopes on the SHP-2 protein, supporting consistent detection across denaturing gel-based assays and fixed-tissue IHC workflows commonly used in cell signalling and developmental biology research.