Anti-SHP-1 Antibody

The Antibodies.com rabbit polyclonal reagent targets SHP-1, the non-receptor protein tyrosine phosphatase encoded by the PTPN6 gene. SHP-1 acts as a critical negative regulator of intracellular signaling cascades in hematopoietic lineages, where it modulates lymphocyte activation, cytokine receptor output, and downstream JAK-STAT activity. The unconjugated antibody is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, and is packaged as a 100 µL vial for routine immunoblotting, immunohistochemistry, and immunofluorescence workflows. Validated reactivity spans human, mouse, and rat samples, making it a flexible reagent for studies examining immune cell signaling, hematopoiesis, and SHP-1's role in tumor suppression and inflammatory disease models.