Anti-SHMT2 Antibody

SHMT2 (Serine Hydroxymethyltransferase 2, mitochondrial) is a key enzyme in cellular one-carbon metabolism, catalyzing the conversion of serine to glycine and supplying one-carbon units for nucleotide biosynthesis and methylation pathways. Aberrant SHMT2 expression has been documented in multiple cancer types and is studied in the context of mitochondrial bioenergetics, redox balance, and hypoxia-driven metabolic adaptation.

This polyclonal rabbit antibody from Antibodies.com targets SHMT2 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples. The unconjugated reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial ready to aliquot for repeated experiments.

Applications include detection of endogenous SHMT2 protein in whole-cell lysates, fixed tissue sections, and cultured cells, as well as co-localization studies examining mitochondrial distribution. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which is useful when probing full-length SHMT2, detecting isoform variants, or characterizing metabolic enzyme complexes in cancer metabolism, immunology, and cell biology research. For research use only.