Anti-SHMT1 Antibody

SHMT1 (Serine Hydroxymethyltransferase 1, cytoplasmic) catalyzes the reversible conversion of serine to glycine using tetrahydrofolate as a cofactor, feeding one-carbon units into folate metabolism. This rabbit polyclonal IgG reagent from Antibodies.com targets SHMT1 and supports Western blot and immunohistochemistry workflows across human, mouse, and rat samples, supplied as 100 µl of unconjugated antiserum.

Applications include studies of one-carbon metabolism, nucleotide biosynthesis, and cancer cell proliferation where cytoplasmic serine-glycine flux is under investigation. The polyclonal format increases the likelihood of recognizing multiple epitopes on the target, an advantage when probing denatured lysates or fixed tissue sections where a single monoclonal epitope may be masked.

Researchers commonly apply this reagent to track SHMT1 expression levels in tumor versus matched normal tissue, to assess responses to serine or glycine deprivation, and to characterize knockdown or overexpression phenotypes in cell line models. Store refrigerated at the temperature indicated on the vial; aliquot to avoid repeated freeze-thaw cycles.