Anti-SHC3 Antibody

Raised in rabbit against the neuronal adaptor protein SHC3 (also known as ShcC or N-Shc), this unconjugated polyclonal reagent from Antibodies.com is supplied in a 100 µL vial and is validated for Western blot and immunohistochemistry on human and mouse samples. The antibody should be stored refrigerated and protected from repeated freeze-thaw cycles to preserve immunoglobulin activity.

SHC3 is the brain-enriched member of the SHC adaptor family, coupling activated receptor tyrosine kinases to downstream Ras/MAPK and PI3K signaling in differentiating neurons, and is therefore of interest in studies of neurotrophin responses, neuronal development, and neurodegenerative disease models. In Western blot, the reagent detects the expected SHC3 band in lysates from rodent brain and from transfected cell lines; in IHC it labels neuronal populations, supporting tissue-based mapping of ShcC expression. Researchers commonly apply it at working dilutions optimized for chemiluminescent or chromogenic detection depending on the secondary reagent chosen.