Anti-SHC1 (phospho Y427) Antibody - Identical to Abcam (ab194782)

SHC1 is a modular adaptor protein containing SH2 and PTB domains that couples activated receptor tyrosine kinases to the Ras-MAPK cascade. Phosphorylation at tyrosine 427 generates a docking site recognized by the Grb2 SH2 domain, making phospho-Y427 SHC1 a sensitive marker of upstream growth factor and integrin input. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against a phosphorylated Y427 peptide and selectively recognizes SHC1 only when modified at this residue, across human, mouse, and rat samples. Validated for Western blot, immunohistochemistry, and immunofluorescence, the antibody is supplied as 200 µl of stock in a single vial compatible with standard chemiluminescent and fluorescent detection workflows.