Anti-Shc1 (Ab-427) Antibody

Produced by Antibodies.com as a 100 µL aliquot of unconjugated polyclonal serum, this reagent was raised in rabbit against the human Shc1 adaptor protein and is validated for Western Blot, Immunohistochemistry, and Immunofluorescence workflows on human samples. Shc1 operates as a phosphotyrosine adaptor that couples activated receptor tyrosine kinases to downstream Ras-MAPK signaling, so antibodies raised to the Ab-427 region are routinely used to follow receptor-proximal phosphorylation events, ERK pathway activity, and Shc1 expression across cell lysates and tissue sections. Because the antibody is supplied unconjugated, end users can pair it with HRP, biotin, or fluorophore-conjugated secondary reagents of their choice, and the polyclonal response provides broad epitope coverage that recognizes the p46, p52, and p66 Shc1 isoforms generated by alternative translation initiation from the same transcript.