Anti-Shc1 (Ab-349) Antibody

This rabbit polyclonal reagent from Antibodies.com targets the SHC Adaptor Protein 1 (Shc1) at the Ab-349 epitope. Raised in rabbit and supplied unconjugated in a 100 µL vial, the antibody is validated for Western blot and immunofluorescence workflows across human, mouse, and rat samples.

Shc1 functions as a scaffolding adapter downstream of activated receptor tyrosine kinases, linking phosphorylated receptor tails to Ras-MAPK signaling through its SH2 and PTB domains. The protein couples activated receptors to downstream effectors and is commonly monitored to detect growth factor–stimulated signaling activity in cell lysates and tissue sections.

For handling, aliquot the stock into smaller working volumes to limit freeze-thaw cycles and preserve binding activity. The product is intended for research use only.