Anti-Shb (phospho-Y246) Antibody

Shb (Src homology 2 domain-containing adapter protein B) is an SH2-bearing adaptor that links receptor tyrosine kinase activation to downstream pathways controlling angiogenesis, hematopoietic cell function, and glucose uptake. Phosphorylation at tyrosine 246 generates a docking site recognized by partner SH2 domains, and tracking this modification is central to studies of VEGFR signaling, insulin receptor crosstalk, and T-cell receptor pathways.

This rabbit polyclonal reagent from Antibodies.com is raised against a phosphorylated epitope surrounding Y246 of human Shb, enabling selective detection of the activated, phosphorylated form rather than total Shb protein. It is validated for immunohistochemistry on formalin-fixed tissue sections and shows reactivity with both Human and Mouse samples, supporting translational work spanning rodent disease models and patient specimens.

Supplied as 100 µl of affinity-purified IgG at 1 mg/ml in phosphate buffered saline (PBS, pH ~7.2) containing 0.05% sodium azide as a preservative. The unconjugated format lets researchers select their own detection chemistry—HRP, biotin, or fluorophore—based on the IHC platform in use. Store refrigerated in the original vial, protect from light, and avoid repeated freeze-thaw cycles to preserve phospho-specific binding activity. Intended for research use only.