Anti-SH3KBP1 Antibody

This unconjugated rabbit polyclonal IgG primary antibody from Antibodies.com recognizes SH3KBP1, also called CIN85, in human and mouse samples. Listed for Western blot (WB), the 50 µl reagent can be paired with a labeled anti-rabbit IgG secondary antibody for chemiluminescent, fluorescent, or affinity-based detection on PVDF or nitrocellulose membranes.

SH3KBP1 is a multifunctional adaptor protein with three N-terminal SH3 domains, a proline-rich region, and a C-terminal coiled-coil region. It participates in Cbl-linked receptor ubiquitination, clathrin-mediated internalization, endosomal sorting, actin remodeling, immune-receptor signaling, and cell adhesion. Researchers can use this antibody to compare SH3KBP1 abundance in human and mouse whole-cell lysates or tissue extracts and to study pathways related to B-cell receptor activation, podocyte and kidney biology, neuronal vesicle cycling, and tumor-cell migration or invasion. The unconjugated format also allows adaptation to co-immunoprecipitation workflows for examining complexes containing Cbl-family proteins and endophilin partners.

Prepare working aliquots and refrigerate them for repeated experiments. For longer retention, freeze at -20 °C or below and limit freeze-thaw cycles to help preserve binding activity. For research use only.