Anti-SH3GLB2 Antibody

Raised in rabbit against a recombinant immunogen, this polyclonal IgG reagent from Antibodies.com detects endogenous Endophilin B2 (SH3GLB2), a lipid-binding protein best known for its N-terminal BAR domain that senses and tubulates curved membranes and a C-terminal SH3 module that docks proline-rich partners such as Bcl-xL and dynamin. The 50 µl vial is supplied unconjugated, leaving the investigator free to conjugate HRP, biotin, or a fluorophore of choice for WB, IHC, and downstream immunoprecipitation workflows.

The antibody has been validated across human, mouse, and rat samples, supporting comparative studies of mitochondrial outer-membrane remodeling, mitophagy flux, and Bax/Bak-driven apoptotic signaling. Because polyclonal sera recognize multiple epitopes, they are well suited to expression profiling across heterogeneous tissues and to tracking shifts in SH3GLB1/SH3GLB2 balance under cellular stress, hypoxia, or chemotherapeutic challenge.

For routine use, aliquot upon receipt and store refrigerated; avoid repeated freeze-thaw cycles to preserve affinity for longitudinal autophagy and cancer-biology experiments.