Anti-SH2B1 Antibody

SH2B1 is an SH2 domain-containing adaptor protein that participates in JAK-STAT and receptor tyrosine kinase signaling, with documented roles in leptin sensitivity, growth hormone response, and neuronal development. This rabbit polyclonal antibody from Antibodies.com is raised against the human target and supplied as an unconjugated preparation of 100 µL. Validated applications include western blot, immunohistochemistry on formalin-fixed sections, and immunofluorescence, supporting detection of endogenous SH2B1 in cell lysates and tissue samples. Researchers studying metabolic regulation, obesity-associated loci, and cytokine-driven pathways use this reagent to probe SH2B1 expression and to map its interactions with JAK2, IRS1, IRS2, and related signaling partners. The polyclonal format yields recognition of multiple epitopes, which can be useful when assessing expression across tissues or in samples where single-epitope coverage is limiting. Storage at -20 °C in working aliquots helps preserve activity across repeated freeze-thaw cycles; for short-term use the antibody can be kept refrigerated. For research use only.