Anti-SGK1 Antibody

This rabbit polyclonal antibody targets SGK1 (Serum and Glucocorticoid-regulated Kinase 1), a serine/threonine kinase of the AGC family that is transcriptionally activated by glucocorticoids and serum stimulation. SGK1 phosphorylates downstream effectors involved in epithelial sodium channel (ENaC) regulation, cellular volume control, renal sodium reabsorption, and glucocorticoid-dependent gene expression, making it a focal point in research on hypertension, metabolic disease, and stress-response signaling.

Validated for Western blot, immunohistochemistry, and immunofluorescence workflows, the reagent detects endogenous SGK1 in human, mouse, and rat sample preparations. The unconjugated format allows researchers to pair it with their own secondary antibody-HRP, fluorophore, or biotin conjugates for custom detection setups. The polyclonal antibody is supplied in a 100 µl volume, enabling multiple immunostaining or blotting experiments.

From Antibodies.com, this primary antibody supports studies investigating aldosterone and mineralocorticoid signaling, diabetic nephropathy, and the kinase's emerging roles in tumor cell survival and chemoresistance pathways.