Anti-SGCG Antibody

This unconjugated Rabbit polyclonal antibody from Antibodies.com detects gamma-sarcoglycan (SGCG), a transmembrane glycoprotein component of the sarcoglycan subcomplex within the dystrophin-associated glycoprotein complex of skeletal and cardiac muscle. The reagent is raised in Rabbit, supplied as an IgG preparation in 200 µL, and validated for Western blot (WB) and immunohistochemistry (IHC) on human samples.

Gamma-sarcoglycan is encoded by SGCG, a gene in which loss-of-function mutations cause autosomal recessive limb-girdle muscular dystrophy type 2C (LGMD2C), historically termed severe childhood autosomal recessive muscular dystrophy (SCARMD). In affected muscle, the missing or unstable gamma-sarcoglycan destabilizes the rest of the sarcoglycan complex, weakening the sarcolemma and triggering cycles of fiber degeneration and regeneration. Researchers studying sarcoglycanopathies, dystrophin complex assembly, sarcolemmal integrity, and neuromuscular disease biology routinely probe muscle biopsy sections and lysates with anti-SGCG reagents.

As an unconjugated polyclonal reagent, the antibody can be paired with user-selected HRP, biotin, or fluorophore secondary detection systems chosen for the assay at hand. Polyclonal binding broadens tolerance for minor epitope variation that may exist between patient samples. Stated reactivity is human; cross-reactivity with other species has not been characterized. The 200 µL format supports multiple membrane-probing rounds and several IHC staining runs. Store refrigerated upon arrival and protect from repeated freeze-thaw cycles to preserve activity; aliquoting on first use is recommended.