Anti-SGCG Antibody

Raised in rabbits against human γ-sarcoglycan, this unconjugated polyclonal IgG reagent from Antibodies.com targets the SGCG subunit of the dystrophin-associated glycoprotein complex, a transmembrane assembly anchored at the sarcolemma of skeletal and cardiac muscle. It is supplied as 100 µl of antibody and is validated for Western blot analysis of cell and tissue lysates and for immunohistochemistry on human muscle sections, where the reagent highlights the characteristic membrane-localized γ-sarcoglycan staining pattern. Investigators studying limb-girdle muscular dystrophy type 2C (LGMD2C) and related sarcoglycanopathies use this antibody to confirm loss or reduction of sarcolemmal γ-sarcoglycan expression in patient biopsies, to map genotype–phenotype correlations across disease-causing SGCG mutations, and to interrogate dystrophin-associated complex integrity alongside the α-, β-, and δ-sarcoglycan subunits. The polyclonal format recognizes multiple epitopes across the target, which supports reliable detection even when the protein is truncated, misfolded, or expressed at low levels in pathological samples, and the unconjugated IgG preparation leaves users free to choose a secondary label matched to their preferred detection chemistry.