Anti-SGCG Antibody

The Sarcoglycan Gamma (SGCG) protein is a transmembrane component of the dystrophin-associated glycoprotein complex (DGC) in striated muscle, anchoring the cytoskeleton to the extracellular matrix through the sarcoglycan subcomplex alongside alpha-, beta-, and delta-sarcoglycan. This affinity-purified polyclonal reagent from Antibodies.com was raised in rabbit and is offered as an unconjugated IgG preparation supplied at 100 µl, suitable for Western blot detection of human SGCG in skeletal muscle lysates and cultured myotubes. The antibody targets the gamma-sarcoglycan subunit, whose loss-of-function mutations are linked to autosomal recessive limb-girdle muscular dystrophy type 2C (LGMD2C), making robust immunoblot detection of the native approximately 35 kDa protein useful for confirming expression in patient-derived tissue, characterizing knockout or knockdown models, and screening for CRISPR-edited rescue constructs. Researchers studying sarcolemma integrity, dystrophinopathies, and cardiomyopathy-associated DGC remodeling will find this reagent a reliable human-reactive probe for routine SDS-PAGE and immunoblotting workflows.