Anti-SFN Antibody

Stratifin, the product of the SFN gene and commonly referenced as 14-3-3σ, is a p53-responsive adaptor of the 14-3-3 family that enforces the G2/M DNA-damage checkpoint, directs epithelial differentiation, and stabilizes keratin networks in stratified tissue. The Antibodies.com polyclonal antibody to this target is raised in rabbit and supplied as 100 µL of unconjugated antiserum, validated for western blot, immunohistochemistry, and immunofluorescence workflows with human, mouse, and rat samples. It is a routine choice for profiling 14-3-3σ status in breast, prostate, and gastric tumor specimens, characterizing keratinocyte maturation in skin and mucosal tissue, and probing DNA-damage signaling in cell-culture models. Store refrigerated, aliquot upon first use to limit freeze-thaw cycling, and protect from light when pairing with fluorescent secondary antibodies.