Anti-SF3B3 Antibody

Rabbit polyclonal IgG from Antibodies.com targets SF3B3 (Splicing Factor 3b Subunit 3), a core component of the U2 small nuclear ribonucleoprotein complex essential for pre-mRNA splicing. SF3B3 contributes to branch point recognition during spliceosome assembly, and antibodies against it are widely used to probe splicing factor expression, subcellular localization, and U2 snRNP integrity in fixed and lysed samples. This unconjugated reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows, giving laboratories flexibility across protein detection, tissue staining, and imaging experiments. It reacts with human, mouse, and rat samples, supporting translational studies in multiple model systems and enabling comparative work in oncology, neurobiology, and RNA processing research. Supplied as 200 µl of polyclonal antibody, the reagent suits investigations of spliceosome composition, splicing dysregulation in malignancies, and RNA metabolic defects. Researchers will find it valuable for cell culture lysates, frozen sections, and paraffin-embedded tissue. For research use only.