Anti-SETDB1 Antibody

This rabbit polyclonal antibody targets SETDB1, a nuclear histone methyltransferase that catalyzes trimethylation of histone H3 at lysine 9 (H3K9me3) and is central to heterochromatin maintenance and transcriptional silencing at endogenous retroviruses and germline gene loci. From Antibodies.com, the reagent is supplied as 100 µl of unconjugated antiserum raised in rabbit, validated for Western blot and immunohistochemistry on human, mouse, and rat samples. SETDB1 is studied extensively in embryonic stem cell pluripotency, neural crest specification, and in oncogenic contexts where its dysregulation drives proliferation and invasion in melanoma, lung, and hepatocellular carcinoma models. The polyclonal format recognizes multiple epitopes across the full-length protein, supporting detection of isoforms and post-translationally modified forms under denaturing conditions, and pairs with standard HRP or fluorescence-labeled secondary antibodies for chemiluminescent or immunofluorescent readout. Aliquot upon first thaw to limit freeze-thaw cycles and store frozen; refrigerated working aliquots remain stable for short-term use. Each vial ships with batch-validated performance data and is intended for research use only in academic and industrial laboratories.