Anti-SETD8 Antibody

An affinity-purified rabbit polyclonal reagent from Antibodies.com targeting SETD8 (also called KMT5A or PR-Set7), a nuclear histone methyltransferase that monomethylates histone H4 at lysine 20. Validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human, mouse, and rat samples, the unconjugated antibody is supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. SETD8 plays essential roles in S-phase progression, mitotic chromosome condensation, the DNA damage response, and replication-coupled chromatin maturation, making this antibody useful for cell-cycle studies, epigenetics research, and investigations of aberrant H4K20 methylation in cancer and developmental models. The polyclonal format improves tolerance for minor epitope variation across species, while the 50% glycerol cryoprotectant permits storage at -20 °C with minimal freeze-thaw damage to aliquoted working stocks.