Anti-SERPINB9 Antibody

This polyclonal antibody from Antibodies.com targets SERPINB9 (Serpin Family B Member 9), an intracellular serine protease inhibitor widely recognized in immunology and oncology research. SERPINB9, also known as PI9, is best characterized for its ability to neutralize granzyme B released by cytotoxic T lymphocytes and natural killer cells, thereby shielding target cells from granzyme B-mediated apoptosis. Because of this role, the protein is frequently studied in the context of tumor immune evasion, cytotoxic lymphocyte biology, and inflammation.

Raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µl vial, this reagent is validated for Western blot (WB) and immunofluorescence (IF) applications on human samples. The unconjugated format gives researchers flexibility to pair the antibody with their preferred secondary detection system, including HRP, biotin, or fluorophore conjugates, depending on the experimental design.

Typical uses include profiling SERPINB9 expression across tumor tissue panels, investigating resistance mechanisms of cancer cells to cytotoxic immune attack, and exploring apoptosis-related signaling in cell-based models. For best results, aliquot upon receipt and store at -20°C, avoiding repeated freeze-thaw cycles; protect from light when working with downstream fluorescent detection workflows.