Anti-SERPINB6 Antibody

Antibodies.com provides a polyclonal antibody raised in Rabbit and validated for the detection of SERPINB6, a cytoplasmic serine protease inhibitor also known as PI-6 or CAP. Belonging to the clade B serpin family, SERPINB6 guards intracellular environments against proteases released during cellular stress, including neutrophil elastase, cathepsin G, and mast cell chymase. Loss-of-function mutations in SERPINB6 have been identified as a cause of autosomal recessive non-syndromic hearing loss (DFNB91), giving this antibody particular utility in auditory and genetic research programs.

Supplied as a 100 µl volume of unconjugated reagent, this reagent performs across Western blot, immunohistochemistry, and immunofluorescence workflows on human samples. Investigators working on apoptosis regulation, granzyme-mediated cytotoxicity, and innate immunity pathways routinely employ SERPINB6-specific antibodies to map inhibitor distribution in protease-rich tissues such as the inner ear, hematopoietic lineages, and mucosal epithelia.