Anti-SERPINA3 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets SERPINA3, the serine protease inhibitor widely known as alpha-1-antichymotrypsin (AACT). Raised in rabbit hosts and supplied at 100 µl per vial, the antibody is validated for Western blot and immunohistochemistry workflows against human samples, supporting studies of acute-phase inflammation, hepatic regulation, and the pathological deposition of AACT within amyloid plaques characteristic of Alzheimer's disease brain tissue.

SERPINA3 is strongly expressed in hepatocytes and upregulated during the inflammatory response, where it inhibits neutrophil cathepsin G and mast cell chymase. Researchers investigating hepatocellular carcinoma, lung adenocarcinoma, and neurodegeneration rely on consistent anti-AACT detection to track disease-associated changes in protein abundance. The polyclonal format provides multiple epitope recognition, useful when target conformation may vary between denatured and native preparations.

For best results, refrigerate the vial upon arrival, aliquot to avoid repeated freeze-thaw cycles, and protect from light. Brief centrifugation before opening recovers any aggregated protein at the vial bottom. The reagent is intended for research use only and is not validated for diagnostic or therapeutic applications.